S-BIAD453alpha

The expression of cancer-testis antigens is associated with immune cell infiltration in the microenvironment of non-small cell lung cancer

Released 2023-02-07
Feria Hikmet Noraddin, Cecilia Lindskog

Content

  • 64 images
  • Study size: 24.5GiB
  • N files: 64
  • Filetype breakdown:
    • .svs: 64 (24.5GiB)
Patients diagnosed with non-small cell lung cancer (NSCLC) have access to immune checkpoint inhibitors which are now routinely used in medical care. However, durable benefits are only measured in a minority of patients. A tumor's antigenic landscape (tumor-associated antigens, TAAs) can be utilized for anticancer immune response, and cancer-testis antigens (CTAs) are known targets of humoral and cellular immune reactions. The current study aimed to characterize CTA expression in non-small cell lung cancer (NSCLC) in relation to the immune microenvironment. Here, we present the raw image data for eight cancer-testis antigens (DPEP3, EZHIP, MAGEA4, MAGEB2, MAGEC2, PAGE1, PRAME, and TKTL1) that were selected for detailed immunohistochemical protein profiling in 1-millimeter tissue punch-outs from 328 NSCLC patients.

Study information

Organism
Homo sapiens (human)
Imaging type
bright-field microscopy
License
CC0

Viewable images

Image ID Preview Filename Dimensions
(T, C, Z, Y, X)		 Download Size Actions
IM1 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide3.svs (1, 3, 1, 42281, 45816) 412.5MiB
IM2 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide5.svs (1, 3, 1, 40508, 47808) 392.2MiB
IM3 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide8.svs (1, 3, 1, 35271, 47808) 274.7MiB
IM4 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide1.svs (1, 3, 1, 42925, 49800) 399.6MiB
IM5 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide6.svs (1, 3, 1, 39944, 49800) 366.5MiB
IM6 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide2.svs (1, 3, 1, 41233, 49800) 424.9MiB

All images

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Image ID Filename Download Size Actions
IM1 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide3.svs 412.5MiB Download
IM2 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide5.svs 392.2MiB Download
IM3 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide8.svs 274.7MiB Download
IM4 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide1.svs 399.6MiB Download
IM5 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide6.svs 366.5MiB Download
IM6 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide2.svs 424.9MiB Download
IM7 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide1.svs 441.0MiB Download
IM8 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide8.svs 245.2MiB Download
IM9 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide6.svs 388.3MiB Download
IM10 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide2.svs 410.8MiB Download
IM11 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide7.svs 383.0MiB Download
IM12 MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide5.svs 430.6MiB Download
IM13 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide3.svs 493.5MiB Download
IM14 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide4.svs 359.0MiB Download
IM15 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide3.svs 409.5MiB Download
IM16 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide6.svs 373.0MiB Download
IM17 MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide1.svs 440.6MiB Download
IM18 MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide8.svs 265.3MiB Download
IM19 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide8.svs 259.3MiB Download
IM20 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide2.svs 411.3MiB Download
IM21 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide2.svs 418.9MiB Download
IM22 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide3.svs 432.5MiB Download
IM23 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide1.svs 424.1MiB Download
IM24 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide8.svs 257.8MiB Download
IM25 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide5.svs 446.8MiB Download
IM26 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide7.svs 380.1MiB Download
IM27 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide2.svs 429.8MiB Download
IM28 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide4.svs 439.6MiB Download
IM29 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide4.svs 422.5MiB Download
IM30 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide5.svs 454.1MiB Download
IM31 MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide7.svs 342.0MiB Download
IM32 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide7.svs 331.8MiB Download
IM33 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide3.svs 455.9MiB Download
IM34 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide5.svs 415.4MiB Download
IM35 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide1.svs 396.8MiB Download
IM36 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide7.svs 348.1MiB Download
IM37 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide7.svs 348.0MiB Download
IM38 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide8.svs 267.3MiB Download
IM39 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide6.svs 367.3MiB Download
IM40 MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide3.svs 473.9MiB Download
IM41 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide8.svs 262.1MiB Download
IM42 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide6.svs 367.4MiB Download
IM43 DPEP3/DPEP3_(HPA058607)_75_BOMI2_slide1.svs 432.5MiB Download
IM44 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide4.svs 398.5MiB Download
IM45 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide2.svs 680.1MiB Download
IM46 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide4.svs 395.7MiB Download
IM47 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide1.svs 427.9MiB Download
IM48 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide4.svs 394.6MiB Download
IM49 TKTL1/TKTL1_(HPA029155)_1500_BOMI2_slide7.svs 348.3MiB Download
IM50 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide5.svs 405.6MiB Download
IM51 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide1.svs 451.7MiB Download
IM52 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide7.svs 366.8MiB Download
IM53 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide8.svs 259.4MiB Download
IM54 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide3.svs 429.4MiB Download
IM55 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide2.svs 426.0MiB Download
IM56 MAGEB2/MAGEB2_(HPA074544)_350_BOMI2_slide5.svs 393.3MiB Download
IM57 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide3.svs 468.3MiB Download
IM58 MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide6.svs 394.1MiB Download
IM59 EZHIP (CXorf67)/EZHIP_(HPA006128)_140_BOMI2_slide6.svs 383.2MiB Download
IM60 MAGEC2/MAGEC2_(HPA062230)_700_BOMI2_slide6.svs 345.1MiB Download
IM61 PRAME/PRAME_(HPA045153)_1300_BOMI2_slide4.svs 406.9MiB Download
IM62 MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide2.svs 418.1MiB Download
IM63 MAGEA4/MAGEA4_(CAB040535)_25000_BOMI2_slide4.svs 408.2MiB Download
IM64 PAGE1/PAGE1_(HPA003473)_900_BOMI2_slide5.svs 409.4MiB Download